Sunday, December 25, 2011

Chennai Kitchen (Brentford, London, by padean)

Chennai Kitchen is a takeaway based in Ealing, London. The Chennai Kitchen offer great tasting Tandoori dishes, Vegetable dishes, Chicken dishes, Lamb dishes, Seafood dishes and Much more. Order online at Chennai Kitchen Ealing, London

Chennai Kitchen is a takeaway based in Ealing, London. The Chennai Kitchen offer great tasting Tandoori dishes, Vegetable dishes, Chicken dishes, Lamb dishes, Seafood dishes and Much more. Order online at Chennai Kitchen Ealing, London show less

Source: http://www.qype.co.uk/review/2607364

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Saturday, December 24, 2011

Transaction Analysis: Gio Dealt to Washington by R.J. Anderson and Kevin Goldstein

December 23, 2011

by R.J. Anderson and Kevin Goldstein

Re-signed LHP John Danks to a five-year deal worth $65 million [12/21]

Kenny Williams, ya?ll. The most unpredictable general manager in the game strikes again. After uttering the term ?rebuilding? earlier this offseason and trading his team?s closer, Williams decides against dealing the team?s most attractive starting pitcher and opted instead to give him a five-year extension at market value. The deal itself is fine. Danks is a good pitcher with adjusted-Fair Run Averages over the last four seasons of 117, 95, 108, and 108.

Source: http://www.baseballprospectus.com/article.php?articleid=15728

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Blood progenitor cells receive signals from niche cells and the daughter blood cells they create

Blood progenitor cells receive signals from niche cells and the daughter blood cells they create

Thursday, December 22, 2011

Maintaining balance is crucial. In Drosophila, the common fruit fly, the creation and maintenance of the blood supply requires such balance.

UCLA stem cell scientists have now uncovered that two-way signaling from two different sets of cells is necessary for that balance, both to ensure enough blood cells are made to respond to injury and infection and that the blood progenitor cell population remains available for future needs.

The stem cell-like blood progenitor cells ? which contribute to the cells of the adult fruit fly's blood supply ? receive signals from cells that live in a nearby safe zone, or niche. These signals keep the progenitors in the same stem cell-like state so, when needed, they can begin differentiating into blood cells.

And in a new discovery, the UCLA stem cell scientists found that the blood progenitor cells receive critical signals back from the daughter blood cells they create, telling the progenitor cells when enough blood cells have been made and it's time to stop differentiating.

The new discovery of the "back talk" from the daughter blood cells appears Dec. 23, 2011 in the peer-reviewed journal Cell.

"The cells in the niche provide a safe environment to support blood progenitor cells," said study co-senior author Dr. Julian A. Martinez-Agosto, an assistant professor of human genetics and pediatrics and a researcher with the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA. "When the blood progenitor cells receive signals from the niche cells it creates an environment for those cells to maintain their potential and not differentiate."

Previous studies have shown that when you remove the niche cells, the blood progenitor cells differentiate unchecked. Ultimately, the fruit fly runs out of blood progenitor cells and is not able to make new blood cells to mount an immune response to infection or injury, Martinez-Agosto said.

The new findings by Martinez-Agosto and study co-senior author Utpal Banerjee, a Broad center researcher and the Irving and Jean Stone Professor and chairman of molecular, cell and developmental biology in Life Sciences, identified additional signals not coming from the niche cells. The new signals were coming from the daughter blood cells the progenitors were making, a surprising discovery, Banerjee said.

Martinez-Agosto and Banerjee noted in the four-year study that once the progenitors cells had begun differentiating and the blood cells they were creating became mature, the progenitors became very quiescent, or quiet, and did not multiply. They theorized that there must be a signal coming from the daughter cells that told the progenitors to stop multiplying and differentiating.

"It was a very surprising finding, because there was no reason to suspect that the differentiating cells had any role at all in the process," Banerjee said. "It's always been the paradigm in stem cell biology that all that was needed was the signaling from the niche cells to maintain the progenitor population. Now, we've shown that you also need the signals from the daughter cells to help maintain the progenitor cell population."

The signaling from the niche cells that maintains the progenitor population is called Hedgehog. In this study, the scientists showed that the daughter cells are sending back a signal to the progenitors that is mediated by Adenosine deaminase growth factor A (Adgf-A). The signal regulates extracellular levels of adenosine, which opposes or counters the effects of Hedgehog signaling.

"We've shown that adenosine as a molecule is really important for regulating the proliferation of progenitor cells in blood. And it requires a delicate balance ? just enough signaling to give you more blood cells, but not so much that all the progenitor cells are lost," Martinez-Agosto said. "Maybe other progenitors or stem cells are using the same signaling to determine when to differentiate or not."

The team used the fruit fly because it is a very accessible model organism in which genes can be easily manipulated and their effects on cells monitored, Martinez-Agosto said. They dissected the fly lymph gland, where blood cells are made, and used green florescence to label progenitors and their daughter cells to determine when they were differentiating.

Going forward, the team will try to understand if the progenitor cells can sense the adenosine in their microenvironment under stress and injury conditions and how cell division biologically counters the niche signaling to promote formation of blood cells.

The study was funded in part by the National Heart, Lung and Blood Institute.

"Our findings reveal signals arising from differentiating cells that are required for maintaining progenitor cell quiescence and that function with the niche-derived signal in maintaining the progenitor state," the study states. "Similar homeostatic mechanisms are likely to be utilized in other systems that maintain relatively large numbers of progenitors that are not all in direct contact with the cells of the niche."

###

University of California - Los Angeles Health Sciences: http://www.uclahealth.org/

Thanks to University of California - Los Angeles Health Sciences for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

This press release has been viewed 25 time(s).

Source: http://www.labspaces.net/116277/Blood_progenitor_cells_receive_signals_from_niche_cells_and_the_daughter_blood_cells_they_create_

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ASUS Transformer Prime games

Transformer Prime

The ASUS Transformer Prime is the first of the next generation Android tablets, packing the brand new quad-core Tegra 3 chip and offering a boatload of performance while managing the battery life.  We've sort of fell in love with it because of it's thin and light build and the way it runs Honeycomb.  It would be the tablet to get if you're in the market for one.

Something that you've heard us (well, mostly me) talk about is how well this beast handles games.  All the beef under the hood is great for normal daily use, and it handles multimedia very nicely, but cracking open some games that really tax the system was something we had to show you.  That's where I come in.  As a child at heart, I love to spend some time playing games on my tablet, and have grown to love more than a few of the great ones developed for Android.  The Prime takes everything to a new level -- both games that have been optimized by NVIDIA, as well as standard OpenGL games built for all devices.  While some of it you just can't tell from a video -- things like colors and lighting effects -- some things you sure can.  Hit the break, and check out how smooth and fluid the Prime runs a handful of CPU eating 3D games that I throw at it.

I love my job.

read more



Source: http://feedproxy.google.com/~r/androidcentral/~3/1A07sAB5wMg/story01.htm

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Friday, December 23, 2011

Wednesday KULR-8 Sports On-Demand 12-21

Story Published: Dec 21, 2011 at 5:33 PM MST

Story Updated: Dec 21, 2011 at 6:35 PM MST

Griz and Cats ready to open Big Sky Conference Basketball race.

Your source for local and surrounding area scores and sports news.
Be sure to watch KULR-8 News @ 6 and 10 M-F, and weekends @ 5
and 10 for complete coverage.

Have a score to report? Sports story idea?
Send to our Sports Department: sports@kulr.com or give us a call, 406-656-8558.

Source: http://www.kulr8.com/sports/local/Wednesday-KULR-8-Sports-On-Demand-12-21-136036498.html

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Negative ads mix with holiday cheer in Iowa (tbo)

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Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/177287197?client_source=feed&format=rss

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Thursday, December 22, 2011

8 US soldiers charged in death of bullied comrade (AP)

NEW YORK ? Even before the Army sent him to Afghanistan, supporters say, Pvt. Daniel Chen was fighting a personal war.

Fellow soldiers at a base in Georgia teased him about his Chinese name, crying out "Chen!" in an exaggerated Asian accent. They called him "Jackie Chen," a reference to the Hollywood action star Jackie Chan. People would ask him repeatedly if he was Chinese, even though he was a native New Yorker.

At one point Chen wrote in his diary that he was running out of jokes to respond with.

Then he was sent overseas, and the hazing began: Soldiers dragged him across a floor, pelted him with stones and forced him to hold liquid in his mouth while hanging upside down, according to diary entries and other accounts cited by a community activist.

On Oct. 3, the 19-year-old Chen was found dead in a guardhouse in Afghanistan with what the Army said was apparently a self-inflicted gunshot wound.

On Wednesday, the Army announced charges against eight soldiers in his death, saying Chen was a victim of illegal hazing. Five of those accused were charged with involuntary manslaughter and negligent homicide. The alleged offenses also included maltreatment, assault and threats.

The military would not discuss the exact circumstances surrounding Chen's death. But family members and community activists said they suspect the bullying may have driven him to suicide.

"Whether suicide or homicide, those responsible for mistreating Danny are responsible for his death," said Elizabeth OuYang, a community activist who is representing his parents, Chinese immigrants who live near New York City's Chinatown neighborhood.

Attorneys for the defendants could not immediately be located. The sister of one of them had no comment. Other relatives could not be reached.

Eugene Fidell, an expert on military law and former president of the National Institute of Military Justice, said bullying has been a recurring problem for the military.

"If there was brutality within the unit, that's a betrayal of the bond of brotherhood," he said. "That is, in theory, the underpinning of what holds a military command together."

He added: "Can I imagine somebody being bullied in the military to the point of taking his or her own life? Yes. These people are young people. You're at an age of vulnerability as well as strength."

In 2010, three Army sergeants were punished after Pvt. Keiffer Wilhelm of Willard, Ohio, killed himself 10 days after arriving in Iraq with a platoon based in Fort Bliss, Texas. Wilhelm's family said he was being bullied and forced to run for miles with rocks in his pockets.

Two sergeants were imprisoned for six months and three months, respectively, on charges of cruelty and maltreatment. The third was convicted of obstructing justice and given a one-grade reduction in pay.

Activists said Chen's case has highlighted the military's poor treatment of Asian-Americans, who remain a tiny percentage of new recruits even as the percentage of blacks, Hispanics, women and other groups has grown.

Pentagon officials would not comment Wednesday on the specifics of the case. But Pentagon spokesman Navy Capt. John Kirby said hazing is not tolerated.

"That's what this uniform requires. And when we don't, there's a justice system in place to deal with it," Kirby said. "That's what we're seeing here in the case of Private Chen."

The details of Chen's alleged hazing came from Facebook and email messages, discussions with cousins and a few pages of Chen's journal released by the Army, OuYang said at a Chinatown news conference.

Chen's relatives said they were encouraged by the charges.

"We realize that Danny will never return, but it gives us some hope," Yen Tao Chen, his father, said through a translator.

Chen was assigned to the 3rd Battalion, 21st Infantry Regiment, 1st Stryker Brigade Combat Team, 25th Infantry Division, based in Fort Wainwright, Alaska.

The Army identified the soldiers charged as 1st Lt. Daniel J. Schwartz, 25, of Maryland (no hometown was given); Staff Sgt. Blaine G. Dugas, 35, of Port Arthur, Texas; Staff Sgt. Andrew J. Van Bockel, 26, of Aberdeen, S.D.; Sgt. Adam M. Holcomb, 29, of Youngstown, Ohio; Sgt. Jeffrey T. Hurst, 26, of Brooklyn, Iowa; Spc. Thomas P. Curtis, 25, of Hendersonville, Tenn; Spc. Ryan J. Offutt, 32, of Greenville, Pa.; and Sgt. Travis F. Carden, 24, of Fowler, Ind.

VanBockel, Holcomb, Hurst, Curtis and Offutt were charged with the most serious offenses, including involuntary manslaughter, negligent homicide, and assault and battery.

Offutt's mother, Carol Tate of Sharon, Pa., told The (Sharon) Herald that she has known about the charges for a while and has talked to her son.

"I think there's a lot of things that really haven't been brought up," she said, but declined further comment.

Schwartz, the only officer among the accused, was charged with dereliction of duty.

The two most serious charges, involuntary manslaughter and negligent homicide, carry prison sentences of up to 10 years and three years, respectively, under military law.

The soldiers are still in Afghanistan but have been relieved of their duties and confined to a different base, the military said. The next step is a hearing to determine if there is enough evidence for a court martial. The proceedings are expected to be held in Afghanistan.

___

Associated Press writers Lolita Baldor at the Pentagon; Meghan Barr, Deepti Hajela and Verena Dobnik in New York; Patrick Quinn in Kabul, Afghanistan; Linda Ball in Dallas; and researchers Monika Mathur, Jennifer Farrar, Barbara Sambriski, Rhonda Shafner and Judith Ausuebel contributed to this story.

Source: http://us.rd.yahoo.com/dailynews/rss/topstories/*http%3A//news.yahoo.com/s/ap/20111222/ap_on_re_us/us_soldier_s_death_investigated

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